Effect of complement Factor H on antibody repertoire and protection elicited by meningococcal capsular group B vaccines containing Factor H binding protein

Bacteria produce surface ligands for host complement regulators including Factor H (FH), which allows the bacteria to evade immunity.Meningococcal Factor H binding protein (FHbp) is both a virulence factor and a vaccine antigen.Antibodies to FHbp can neutralize its function by inhibiting binding of FH to the bacteria and confer robust complement-me

read more